Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes

被引：19

作者：

Posa, Francesca ^{[1
,2
,3
]}

Di Benedetto, Adriana ^{[1
]}

Ravagnan, Giampietro ^{[4
]}

Cavalcanti-Adam, Elisabetta Ada ^{[2
,3
]}

Lo Muzio, Lorenzo ^{[1
]}

Percoco, Gianluca ^{[5
]}

Mori, Giorgio ^{[1
]}

机构：

[1] Univ Foggia, Dept Clin & Expt Med, Viale Pinto 1, I-71122 Foggia, Italy

[2] Heidelberg Univ, Dept Biophys Chem, Jahnstr 29, D-69120 Heidelberg, Germany

[3] Max Planck Inst Med Res, Jahnstr 29, D-69120 Heidelberg, Germany

[4] Univ Venezia Ca Foscari, Spin Acad, Unita Operat Napoli, Glures Srl, I-30175 Venice, Italy

[5] Polytech Univ Bari, Dept Mech Math & Management, Via E Orabona 4, I-70125 Bari, Italy

来源：

MATERIALS | 2020年 / 13卷 / 20期

关键词：

bone; mesenchymal stem cells; biomaterial; polycarbonate; resveratrol; polydatin; osteogenic differentiation; focal adhesions; bone health; MESENCHYMAL STEM-CELLS; OSTEOGENIC DIFFERENTIATION; POLYDATIN; RESVERATROL; TRANSFORMATION; MSCS;

D O I：

10.3390/ma13204471

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.

引用

页码：1 / 12

页数：12

共 42 条

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Experimental design and investigation on the mechanical behavior of novel 3D printed biocompatibility polycarbonate scaffolds for medical applications [J].