Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin

被引：7

作者：

Qiu, Wen-Wei ^{[1
]}

Xu, Jie ^{[1
]}

Liu, Da-Zhi ^{[1
]}

Li, Jing-Ya ^{[1
]}

Ye, Yang ^{[1
]}

Zhu, Xing-Zu ^{[1
]}

Li, Jia ^{[1
]}

Nan, Fa-Jun ^{[1
]}

机构：

[1] Chinese Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 12期

关键词：

synthesis; photoaffinity probe; paeoniflorin;

D O I：

10.1016/j.bmcl.2006.03.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A trifunctional probe (binding element-photoreactive group-affinity tag) of natural product paeoniflorin was designed and synthesized based on the previous primary structure-activity relationship. This new probe is a potential tool for labeling, purification, and identification of the target proteins. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3306 / 3309

页数：4

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