Synthesis of a novel bioactive photoaffinity probe based on a leaf-movement factor with potential high binding affinity to its receptor molecule

被引：8

作者：

Fujii, T ^{[1
]}

Sugimoto, T ^{[1
]}

Yamamura, S ^{[1
]}

Ueda, M ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Chem, Lab Nat Prod, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(03)00287-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nyctinastic leaf-movement is induced by the binding of the leaf-movement factor with a motor cell located in the pulvini of the plant. Some receptors of the leaf-movement factor should be involved in this biological event. We developed a novel photoaffinity probe (1) for the detection of receptor molecules. Probe compound 1 bears a photolabeling group on the 2'-position of the glycon moiety, which is near the potential binding site of the molecule with its receptor. This molecular design would be effective for the improvement of photolabeling yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2497 / 2499

页数：3

共 9 条

[1]

Hatanaka Y, 1994, Bioorg Med Chem, V2, P1367, DOI 10.1016/S0968-0896(00)82088-X

[2]

LEE Y, 1990, PULVINUS MOTOR ORGAN, P130

[3] BIOACTIVE SUBSTANCES FROM LESPEDEZA-CUNEATA LG DON AND THEIR BIOLOGICAL-ACTIVITIES [J].

SHIGEMORI, H ;

SAKAI, N ;

MIYOSHI, E ;

SHIZURI, Y ;

YAMAMURA, S .

TETRAHEDRON, 1990, 46 (02) :383-394

[4] Visualization of the precise structure recognition of leaf-opening substance by using biologically inactive probe compounds: Fluorescence studies of nyctinasty in legumes 2 [J].

Sugimoto, T ;

Yamamura, S ;

Ueda, M .

CHEMISTRY LETTERS, 2002, (11) :1118-1119

[5] Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants [J].

Sugimoto, T ;

Fujii, T ;

Hatanaka, Y ;

Yamamura, S ;

Ueda, M .

TETRAHEDRON LETTERS, 2002, 43 (37) :6529-6532

[6] Fluorescence study on the nyctinasty of Cassia mimosoides L. using novel fluorescence-labeled probe compounds [J].

Sugimoto, T ;

Wada, Y ;

Yamamura, S ;

Ueda, M .

TETRAHEDRON, 2001, 57 (49) :9817-9825

[7] Bioorganic studies on nyctinasty of the plant controlled by a biological clock [J].

Ueda, M ;

Takada, N ;

Yamamura, S .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2002, 75 (11) :2337-2347

[8] Direct observation of the target cell for leaf-movement factor using novel fluorescence-labeled probe compounds: Fluorescence studies of nyctinasty in legumes. Part 1 [J].

Ueda, M ;

Wada, Y ;

Yamamura, S .

TETRAHEDRON LETTERS, 2001, 42 (23) :3869-3872

[9] SYNTHESIS OF D-GALACTOSAMINE DERIVATIVES AND BINDING-STUDIES USING ISOLATED RAT HEPATOCYTES [J].

WONG, TC ;

TOWNSEND, RR ;

LEE, YC .

CARBOHYDRATE RESEARCH, 1987, 170 (01) :27-46

← 1 →