A novel method for the synthesis of 4(3H)-quinazolinones

被引:285
作者
Abdel-Jalil, RJ [1 ]
Voelter, W
Saeed, M
机构
[1] Hashemite Univ, Fac Arts & Sci, Dept Chem, Zarka 13133, Jordan
[2] Univ Tubingen, Inst Physiol Chem, Phys Biochem Abt, D-72076 Tubingen, Germany
[3] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA
关键词
quinazolinone; synthesis; Schiff base; anthranilimide;
D O I
10.1016/j.tetlet.2004.03.003
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Condensation of anthranilamide with aryl. alkyl or heteroaryl aldehydes in refluxing ethanol and the presences of CuCl2 afforded the corresponding 2-substituted quinazolinones in excellent yields. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3475 / 3476
页数:2
相关论文
共 13 条
[1]   PALLADIUM COMPLEX-CATALYZED INTERMOLECULAR REDUCTIVE N-HETEROCYCLIZATION - NOVEL SYNTHESIS OF QUINAZOLINE DERIVATIVES FROM 2-NITROBENZALDEHYDE OR 2-NITROPHENYL KETONES WITH FORMAMIDE [J].
AKAZOME, M ;
YAMAMOTO, J ;
KONDO, T ;
WATANABE, Y .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1995, 494 (1-2) :229-233
[2]  
Armarego W.L.F., 1979, ADV HETEROCYCL CHEM, V24, P1, DOI 10.1016/S0065-2725(08)60507-3
[3]  
Buchanan J.G., 1972, SELECTIVE ORGANIC TR, V2, P1
[4]  
Deepthi KS, 2000, INDIAN J CHEM B, V39, P220
[5]  
KENICHI O, 1985, J MED CHEM, V28, P568
[6]   NONSTEROIDAL ANTIINFLAMMATORY AGENTS - NOVEL PYRAZOLYL DERIVATIVES, 1,2-OXAZOLYL DERIVATIVES, AND 1,3-DIAZINYL DERIVATIVES OF 4(3H)-QUINAZOLINONES [J].
KHALIL, MA ;
SOLIMAN, R ;
FARGHALY, AM ;
BEKHIT, AA .
ARCHIV DER PHARMAZIE, 1994, 327 (01) :27-30
[7]  
López SE, 2000, J CHEM RES-S, P258
[8]  
Lyle F. R., 1985, U.S. Patent, Patent No. [5 973 257, 5973257]
[9]   SYNTHESIS AND USE OF NEW FLUOROGENIC PRECIPITATING SUBSTRATES [J].
NALEWAY, JJ ;
FOX, CMJ ;
ROBINHOLD, D ;
TERPETSCHNIG, E ;
OLSON, NA ;
HAUGLAND, RP .
TETRAHEDRON LETTERS, 1994, 35 (46) :8569-8572
[10]   Novel nonpeptide CCK-B antagonists: Design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists [J].
Padia, JK ;
Field, M ;
Hinton, J ;
Meecham, K ;
Pablo, J ;
Pinnock, R ;
Roth, BD ;
Singh, L ;
Suman-Chauhan, N ;
Trivedi, BK ;
Webdale, L .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (07) :1042-1049