NONSTEROIDAL ANTIINFLAMMATORY AGENTS - NOVEL PYRAZOLYL DERIVATIVES, 1,2-OXAZOLYL DERIVATIVES, AND 1,3-DIAZINYL DERIVATIVES OF 4(3H)-QUINAZOLINONES

被引：27

作者：

KHALIL, MA

SOLIMAN, R

FARGHALY, AM

BEKHIT, AA

机构：

[1] Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 01期

关键词：

D O I：

10.1002/ardp.19943270105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four novel series of 4(3H)-quinazolinone derivatives have been prepared by cyclization of the key intermediates 3-aryl-2-(3-aryl-3-oxopropenyl)-4-(3H)-quinazolinones with different reagents: 3-aryl-1-iminocarbamoyl-1H-pyrazol-5-yl)-4(3H)-quinazolines, 3-aryl-2-(3-aryl-1-thiocarbamoyl-1H-pyrazol-5-yl)-4(3H)-quinazolines, 3-aryl-2-(3-aryl-4,5-dihydro-1,2-oxazol-5-yl)-4(3H)-quinazolinones, and 3-aryl-2-(4-aryl-2-thioxo-1,2,5,6-tetrahydro-1,3-diazin-6-yl)-4(3H)-quinazolines. The anti-inflammatory activity of representatives of these compounds is comparable to or higher than that of proquazone.

引用

页码：27 / 30

页数：4

共 12 条

[1]

AGARWAL R, 1984, J CHEM SOC PAKISTAN, V6, P89

[2]

BANDAVALLI F, 1988, FARMACO, V43, P1019

[3] STUDIES IN ORGANIC MASS-SPECTROMETRY .4. ELECTRON-IMPACT INDUCED FRAGMENTATION OF 2-SUBSTITUTED 3-(5-ISOXAZOLYL)-4(3H)-QUINAZOLINONES OF PHARMACEUTICAL INTEREST [J].