Pharmacokinetics of amprenavir given once or twice a day when combined with atazanavir in heavily pre-treated HIV-positive patients

被引：10

作者：

Guffanti, M ^{[1
]}

De Pascalis, CR

Seminari, DPE

Fusetti, G

Gianotti, N

Bassetti, D

Galli, A

Castagna, A

Lazzarin, A

机构：

[1] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Dept Infect Dis, I-20132 Milan, Italy

[2] Univ Genoa, San Martino Hosp, Clin Infect Dis, Genoa, Italy

来源：

AIDS | 2003年 / 17卷 / 18期

关键词：

D O I：

10.1097/00002030-200312050-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the pharmacokinetics of amprenavir at doses of 600 mg twice a day or 1200 mg once a day, when co-administered to HIV-positive patients with 400 mg a day of atazanavir without a ritonavir booster. Our preliminary results suggest that amprenavir and atazanavir could be co-administered and that amprenavir could be boosted by atazanavir without the need for ritonavir pharmaco-enhancement.

引用

页码：2669 / 2671

页数：3

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