Cardiac transcription factor Csx/Nkx2-5: its role in cardiac development and diseases

被引：170

作者：

Akazawa, H

Komuro, I

机构：

[1] Chiba Univ, Grad Sch Med, Div Cardiovasc Pathophysiol, Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Cardiovasc Sci & Med, Chuo Ku, Chiba 2608670, Japan

来源：

PHARMACOLOGY & THERAPEUTICS | 2005年 / 107卷 / 02期

关键词：

homeobox; transcriptional regulation; cardiac development; congenital heart disease; cardiac hypertrophy; cardioprotection;

D O I：

10.1016/j.pharmthera.2005.03.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During the past decade, an emerging body of evidence has accumulated that cardiac transcription factors control a cardiac gene program and play a critical role in transcriptional regulation during cardiogenesis and during the adaptive process in adult hearts. Especially, an evolutionally conserved homeobox transcription factor Csx/Nkx2-5 has been in the forefront in the field of cardiac biology, providing molecular insights into the mechanisms of cardiac development and diseases. Csx/Nkx2-5 is indispensable for normal cardiac development, and mutations of the gene are associated with human congenital heart diseases (CHD). In the present review, the regulation of a cardiac gene program by Csx/Nkx2-5 is summarized, with an emphasis on its role in the cardiac development and diseases. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：252 / 268

页数：17

共 160 条

[11] Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development [J].