Noninvasive in situ identification and band assignments of some pharmaceutical excipients inside USP vials with FT-near-infrared spectroscopy

被引：12

作者：

Ali, Hassan Refat H. ^{[1
,2
]}

Edwards, Howell G. M. ^{[1
]}

Scowen, Ian J. ^{[1
]}

机构：

[1] Univ Bradford, Univ Analyt Ctr, Sch Life Sci, Bradford BD7 1DP, W Yorkshire, England

[2] Univ Assiut, Fac Pharm, Dept Pharmaceut Analyt Chem, Assiut, Egypt

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2009年 / 72卷 / 04期

关键词：

Near-infrared spectroscopy; Pharmaceuticals excipients; In situ; Lactose hydrate; Anhydrous; REFLECTANCE SPECTROSCOPY; SPECTROMETER;

D O I：

10.1016/j.saa.2008.12.010

中图分类号：

O433 [光谱学];

学科分类号：

070207 [光学];

摘要：

For the manufacture of dosage forms all ingredients must be reliably identified. In this paper, the suitability of FT-NIR spectroscopy to identify potassium sorbate, sodium starch glycollate, calcium ascorbate, calcium carbonate, candelilla wax, maltosextrin, monohydrated and anhydrous lactose inside USP vials was investigated. Differentiation between the anhydrous and monohydrated forms of lactose was found to be possible by studying the regions of the near-infrared spectrum corresponding to the combination and first overtone stretching frequencies of water. The results show unequivocally the potential of FT-NIR spectroscopy for rapid, in situ and non-destructive identification of pharmaceutical excipients. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：890 / 896

页数：7

共 16 条

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[2]

Development and validation of a method for the analysis of a pharmaceutical preparation by near-infrared diffuse reflectance spectroscopy [J].