Costimulation and autoimmunity

被引：99

作者：

Tivol, EA ^{[1
]}

Schweitzer, AN ^{[1
]}

Sharpe, AH ^{[1
]}

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV IMMUNOL RES,BOSTON,MA 02115

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(96)80011-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has seen significant advances in our understanding of the role of the B7-CD28/CTLA-4 pathway in T cell activation and self-tolerance. Recent studies have demonstrated that CTLA-4 is a critical negative regulator of T cell activation and autoreactivity, revealing a previously unsuspected means by which costimulation is involved in the maintenance and breakdown of self-tolerance. Manipulation of this costimulatory pathway in animal models of autoimmunity has shown an important role for this pathway in both the initiation and progression of autoimmune diseases.

引用

页码：822 / 830

页数：9

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