Costimulation and autoimmunity

被引：99

作者：

Tivol, EA ^{[1
]}

Schweitzer, AN ^{[1
]}

Sharpe, AH ^{[1
]}

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV IMMUNOL RES,BOSTON,MA 02115

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(96)80011-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has seen significant advances in our understanding of the role of the B7-CD28/CTLA-4 pathway in T cell activation and self-tolerance. Recent studies have demonstrated that CTLA-4 is a critical negative regulator of T cell activation and autoreactivity, revealing a previously unsuspected means by which costimulation is involved in the maintenance and breakdown of self-tolerance. Manipulation of this costimulatory pathway in animal models of autoimmunity has shown an important role for this pathway in both the initiation and progression of autoimmune diseases.

引用

页码：822 / 830

页数：9

共 66 条

[41] Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus [J].

Morahan, G ;

Huang, DX ;

Tait, BD ;

Colman, PG ;

Harrison, LC .

SCIENCE, 1996, 272 (5269) :1811-1813

[42] PREFERENTIAL DEPENDENCE OF AUTOANTIBODY PRODUCTION IN MURINE LUPUS ON CD86 COSTIMULATORY MOLECULE [J].

NAKAJIMA, A ;

AZUMA, M ;

KODERA, S ;

NURIYA, S ;

TERASHI, A ;

ABE, M ;

HIROSE, S ;

SHIRAI, T ;

YAGITA, H ;

OKUMURA, K .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (11) :3060-3069

[43]

NICKOLOFF BJ, 1994, BLOOD, V83, P2580

[44] The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes [J].

Nistico, L ;

Buzzetti, R ;

Pritchard, LE ;

VanderAuwera, B ;

Giovannini, C ;

Bosi, E ;

Larrad, MTM ;

Rios, MS ;

Chow, CC ;

Cockram, CS ;

Jacobs, K ;

Mijovic, C ;

Bain, SC ;

Barnett, AH ;

Vandewalle, CL ;

Schuit, F ;

Gorus, FK ;

Tosi, R ;

Pozzilli, P ;

Todd, JA .

HUMAN MOLECULAR GENETICS, 1996, 5 (07) :1075-1080

[45]

Perkins D, 1996, J IMMUNOL, V156, P4154

[46]

Perrin PJ, 1996, J IMMUNOL, V157, P1333

[47]

PERRIN PJ, 1995, J IMMUNOL, V154, P1481

[48] DISTINCT ROLES FOR B7-1 (CD-80) AND B7-2 (CD-86) IN THE INITIATION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS [J].

RACKE, MK ;

SCOTT, DE ;

QUIGLEY, L ;

GRAY, GS ;

ABE, R ;

JUNE, CH ;

PERRIN, PJ .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2195-2203

[49] ELEVATED EXPRESSION OF CD80 (B7/BB1) AND OTHER ACCESSORY MOLECULES ON SYNOVIAL-FLUID MONONUCLEAR CELL SUBSETS IN RHEUMATOID-ARTHRITIS [J].

RANHEIM, EA ;

KIPPS, TJ .

ARTHRITIS AND RHEUMATISM, 1994, 37 (11) :1637-1646

[50] ANALYSIS OF LYMPHOCYTE COSTIMULATION IN-VIVO USING TRANSGENIC AND KNOCKOUT MICE [J].

SHARPE, AH .

CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (03) :389-395

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