Proteins in Mesoporous Silicates

被引：581

作者：

Hudson, Sarah ^{[1
]}

Cooney, Jakki ^{[2
]}

Magner, Edmond ^{[1
]}

机构：

[1] Univ Limerick, Dept Chem & Environm Sci, Mat & Surface Sci Inst, Plassey, Co Limerick, Ireland

[2] Univ Limerick, Dept Life Sci, Mat & Surface Sci Inst, Plassey, Co Limerick, Ireland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 45期

关键词：

biocatalysis; functionalization; mesoporous materials; proteins; silicates;

D O I：

10.1002/anie.200705238

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silicates (MPS) have an ordered pore structure with dimensions comparable to many biological molecules. They have been extensively explored as supports for proteins and enzymes in biocatalytic applications. Since their initial discovery, novel syntheses methods have led to precise control over pore size and structure, particle size, chemical composition, and stability, thus allowing the adsorption of a wide variety of biological macromolecules, such as heme proteins, lipases, antibody fragments, and proteases, into their structures. This Review discusses the application of ordered, largepore, functionalized mesoporous silicates to immobilize proteins for biocatalysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8582 / 8594

页数：13

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