Hepatitis C virus-like particle morphogenesis

被引：91

作者：

Blanchard, E

Brand, D

Trassard, S

Goudeau, A

Roingeard, P

机构：

[1] Fac Med Tours, Lab Biol Cellulaire, F-37032 Tours, France

[2] Fac Med Tours, Virol Lab, F-37032 Tours, France

[3] Fac Med Tours, Biol Cellulaire Lab, F-37032 Tours, France

[4] CHU Tours, Tours, France

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 08期

关键词：

D O I：

10.1128/JVI.76.8.4073-4079.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although much is known about the hepatitis C virus (HCV) genome, first cloned in 1989, little is known about HCV structure and assembly due to the lack of an efficient in vitro culture system for HCV. Using a recombinant Semliki forest virus replicon expressing genes encoding HCV structural proteins, we observed for the first time the assembly of these proteins into HCV-like particles in mammalian cells. This system opens up new possibilities for the investigation of viral morphogenesis and virus-host cell interactions.

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收藏

页码：4073 / 4079

页数：7

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