Mimics and cross reactions of relevance to tumour immunotherapy

被引：20

作者：

Apostolopoulos, V ^{[1
]}

Sandrin, MS ^{[1
]}

McKenzie, IFC ^{[1
]}

机构：

[1] Austin Res Inst, Heidelberg, Vic 3084, Australia

来源：

VACCINE | 1999年 / 18卷 / 3-4期

关键词：

MUC1; mimics; cross reactions;

D O I：

10.1016/S0264-410X(99)00197-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MUC1 has been used as a target for immunotherapy and with oxidised mannan in mice there is selective delivery into the class I pathway and the induction of a T1 response. We have also been working in pig-to-human transplantation and of particular interest is the description in humans of natural Ga1 alpha(1,3)Gal antibodies (Abs) which react with pig tissues. A peptide mimic (DAHWESWL) to the Ga1 alpha(1,3)Gal sugar was found in a phage display library and is also mimicked by MUC1 peptides. It was of interest to note that while mice make cytotoxic T cells (CTLs) and little Ab to MUC1, humans make the reverse immune response. It was found that the cross reaction of the natural Ga1 alpha(1,3)Gal Abs in humans to MUC1 was likely to be responsible for the diversion. Cross reactions are therefore an important problem in tumour immunotherapy, although the problem can be overcome by in vitro immunisations. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：268 / 275

页数：8

共 39 条

[21]

HAYES CE, 1974, J BIOL CHEM, V249, P1904

[22] Synthesis of alpha-gal epitopes on influenza virus vaccines, by recombinant alpha 1,3galactosyltransferase, enables the formation of immune complexes with the natural anti-Gal antibody [J].