How APC/C orders destruction

被引：19

作者：

Buschhorn, BA ^{[1
]}

Peters, JM ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 03期

关键词：

D O I：

10.1038/ncb0306-209

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls cell-cycle progression by targeting proteins for destruction by the 26S proteasome. The APC/C is active throughout late mitosis and G1 phase but APC/C substrates are degraded in a specific order. A recent study provides insights into how ordered turnover of substrates is achieved.

引用

收藏

页码：209 / 211

页数：4

相关论文

共 13 条

[1] Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box [J].

Burton, JL ;

Tsakraklides, V ;

Solomon, MJ .

MOLECULAR CELL, 2005, 18 (05) :533-542

[2] The APC subunit Doc1 promotes recognition of the substrate destruction box [J].

Carroll, CW ;

Enquist-Newman, M ;

Morgan, DO .

CURRENT BIOLOGY, 2005, 15 (01) :11-18

[3] Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 [J].

Hagting, A ;

den Elzen, N ;

Vodermaier, HC ;

Waizenegger, IC ;

Peters, JM ;

Pines, J .

JOURNAL OF CELL BIOLOGY, 2002, 157 (07) :1125-1137

[4] KINETIC PROOFREADING - NEW MECHANISM FOR REDUCING ERRORS IN BIOSYNTHETIC PROCESSES REQUIRING HIGH SPECIFICITY [J].

HOPFIELD, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (10) :4135-4139

[5] The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates [J].

Kraft, C ;

Vodermaier, HC ;

Maurer-Stroh, S ;

Eisenhaber, F ;

Peters, JM .

MOLECULAR CELL, 2005, 18 (05) :543-553

[6] Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells [J].

Lindon, C ;

Pines, J .

JOURNAL OF CELL BIOLOGY, 2004, 164 (02) :233-241

[7] Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition [J].

Passmore, LA ;

Barford, D .

EMBO REPORTS, 2005, 6 (09) :873-878

[8] Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition [J].

Passmore, LA ;

McCormack, EA ;

Au, SWN ;

Paul, A ;

Willison, KR ;

Harper, JW ;

Barford, D .

EMBO JOURNAL, 2003, 22 (04) :786-796

[9] The anaphase-promoting complex: Proteolysis in mitosis and beyond [J].

Peters, JM .

MOLECULAR CELL, 2002, 9 (05) :931-943

[10] Mitosis: a matter of getting rid of the right protein at the right time [J].

Pines, J .

TRENDS IN CELL BIOLOGY, 2006, 16 (01) :55-63