The anaphase-promoting complex: Proteolysis in mitosis and beyond

被引：757

作者：

Peters, JM ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

MOLECULAR CELL | 2002年 / 9卷 / 05期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S1097-2765(02)00540-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.

引用

页码：931 / 943

页数：13

共 114 条

[1] Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
Agami, R
Bernards, R
[J]. CELL, 2000, 102 (01) : 55 - 66
[2] The spindle checkpoint
Amon, A
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (01) : 69 - 75
[3] CLOSING THE CELL-CYCLE CIRCLE IN YEAST - G2 CYCLIN PROTEOLYSIS INITIATED AT MITOSIS PERSISTS UNTIL THE ACTIVATION OF G1 CYCLINS IN THE NEXT CYCLE
AMON, A
IRNIGER, S
NASMYTH, K
[J]. CELL, 1994, 77 (07) : 1037 - 1050
[4] Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit
Au, SWN
Leng, XH
Harper, JW
Barford, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2002, 316 (04) : 955 - 968
[5] A mechanism for coupling exit from mitosis to partitioning of the nucleus
Bardin, AJ
Visintin, R
Amon, A
[J]. CELL, 2000, 102 (01) : 21 - 31
[6] Men and sin: What's the difference?
Bardin, AJ
Amon, A
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (11) : 815 - 826
[7] Two different modes of cyclin Clb2 proteolysis during mitosis in Saccharomyces cerevisiae
Bäumer, M
Braus, GH
Irniger, S
[J]. FEBS LETTERS, 2000, 468 (2-3) : 142 - 148
[8] Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a
Bembenek, J
Yu, HT
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) : 48237 - 48242
[9] APCste9/srw1 promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation
Blanco, MA
Sánchez-Díaz, A
de Prada, JM
Moreno, S
[J]. EMBO JOURNAL, 2000, 19 (15) : 3945 - 3955
[10] The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
Brandeis, M
Hunt, T
[J]. EMBO JOURNAL, 1996, 15 (19) : 5280 - 5289

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