Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

被引：403

作者：

Hering, BJ

Wijkstrom, M

Graham, ML

Hårstedt, M

Aasheim, TC

Jie, T

Ansite, JD

Nakano, M

Cheng, J

Li, W

Moran, K

Christians, U

Finnegan, C

Mills, CD

Sutherland, DE

Bansal-Pakala, P

Murtaugh, MP

Kirchhof, N

Schuurman, HJ

机构：

[1] Univ Minnesota, Diabet Inst Immunol & Transplantat, Dept Surg, Minneapolis, MN 55455 USA

[2] Immerge BioTherapeut Inc, Charlestown, MA 02129 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Anesthesia, Denver, CO 80262 USA

[4] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

[5] Univ Minnesota, Dept Vet Populat Med, Vet Med Ctr 225, St Paul, MN 55108 USA

来源：

NATURE MEDICINE | 2006年 / 12卷 / 03期

关键词：

D O I：

10.1038/nm1369

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without GaI-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-GaI pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.

引用

收藏

页码：301 / 303

页数：3

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