Cellular changes in rat brain areas associated with neonatal hippocampal damage

被引：31

作者：

Bernstein, HG

Grecksch, G

Becker, A

Höllt, V

Bogerts, B

机构：

[1] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany

[2] Univ Magdeburg, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 11期

关键词：

calretinin; GFAP; hippocampal damage; model of schizophrenia; nitric oxide synthase/NADPH; diaphorase; number of neurons; ornithine decarboxylase; prefrontal cortex;

D O I：

10.1097/00001756-199908020-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE neonatal destruction of the ventral hippocampus was introduced as a model to recreate features of schizophrenia in the rat. While behavioral consequences of this intervention have been studied in detail, less is known about the cellular processes underlying the deviant behavior. We studied in rats (neonatally or adult lesioned, controls) brain areas receiving or not receiving hippocampal projections. The number of neurons and the expression of the cell markers L-ornithine decarboxylase, nitric oxide synthase/NADPH diaphorase, calretinin and GFAP were estimated. Reduced numbers of neurons and increased immunostaining for ornithine decarboxylase and nitric oxide synthase in the prefrontal, perirhinal and entorhinal cortex of neonatally but not adult lesioned rats or controls demonstrate persistent cellular changes after ventral hippocampus damage. NeuroReport 10:2307-2311 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2307 / 2311

页数：5

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