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Target selectivity in mRNA silencing

被引：28
作者：
Aronin, N [1 ]
机构：
[1] Univ Massachusetts, Worcester, MA 01655 USA
来源：
GENE THERAPY | 2006年 / 13卷 / 06期
关键词：
siRNA; single nucleotide polymorphisms; RISC assembly; Huntington's disease;
D O I：
10.1038/sj.gt.3302726
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targets for small siRNAs. This review will consider recent discoveries in mechanisms of RNA interference and siRNA modifications that improve siRNA selectivity, delivery and performance.
引用
收藏
页码：509 / 516
页数：8
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