Combinatorial synthetic design

被引:38
作者
Oliver, SF [1 ]
Abell, C [1 ]
机构
[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
关键词
D O I
10.1016/S1367-5931(99)80046-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The range and diversity of solid-phase synthetic methodology continues to develop very rapidly, allowing the generation of previously inaccessible compound libraries. The design of such libraries requires consideration of linkage strategies, newly developed solid-phase reactions and emerging solution-phase processes.
引用
收藏
页码:299 / 306
页数:8
相关论文
共 42 条
[1]   Transition-metal-mediated reactions in combinatorial synthesis [J].
Andres, CJ ;
Whitehouse, DL ;
Deshpande, MS .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (03) :353-362
[2]   Application of radical chemistry to solid support synthesis [J].
Berteina, S ;
De Mesmaeker, A .
TETRAHEDRON LETTERS, 1998, 39 (32) :5759-5762
[3]   Higher order iminodiacetic acid libraries for probing protein-protein interactions [J].
Boger, DL ;
Ducray, P ;
Chai, WY ;
Jiang, WQ ;
Goldberg, J .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (17) :2339-2344
[4]   Solid-phase organic reactions III: A review of the literature Nov 96 Dec 97 [J].
Booth, S ;
Hermkens, PHH ;
Ottenheijm, HCJ ;
Rees, DC .
TETRAHEDRON, 1998, 54 (51) :15385-15443
[5]  
Boymond L, 1998, ANGEW CHEM INT EDIT, V37, P1701, DOI 10.1002/(SICI)1521-3773(19980703)37:12<1701::AID-ANIE1701>3.0.CO
[6]  
2-U
[7]   Solid phase synthesis of oxazolidinones via a novel cyclisation/cleavage reaction [J].
Buchstaller, HP .
TETRAHEDRON, 1998, 54 (14) :3465-3470
[8]   Synthesis and screening of linear and cyclic oligocarbamate libraries. Discovery of high affinity ligands for GPIIb/IIIa [J].
Cho, CY ;
Youngquist, RS ;
Paikoff, SJ ;
Beresini, MH ;
Hebert, AR ;
Berleau, LT ;
Liu, CW ;
Wemmer, DE ;
Keough, T ;
Schultz, PG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (31) :7706-7718
[9]   SmI2-mediated sequential radical cyclization/anionic capture of aryl iodides on solid support [J].
Du, XH ;
Armstrong, RW .
TETRAHEDRON LETTERS, 1998, 39 (16) :2281-2284
[10]   Synthesis of diverse tetrahydro-β-carboline-3-carboxamides and -2,3-bis-lactams on a versatile 4-hydroxythiophenol-linked solid support [J].
Fantauzzi, PP ;
Yager, KM .
TETRAHEDRON LETTERS, 1998, 39 (11) :1291-1294