Genetic variation in DTNBP1 influences general cognitive ability

被引：133

作者：

Burdick, KE

Lencz, T

Funke, B

Finn, CT

Szeszko, PR

Kane, JM

Kucherlapati, R

Malhotra, AK

机构：

[1] Zucker Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Dept Psychiat Res, Albert Einstein Coll Med, Glen Oaks, NY 11004 USA

[2] Albert Einstein Coll Med, Dept Psychiat, Glen Oaks, NY USA

[3] Harvard Partners Ctr Genet & Gen, Boston, MA USA

来源：

HUMAN MOLECULAR GENETICS | 2006年 / 15卷 / 10期

关键词：

D O I：

10.1093/hmg/ddi481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.

引用

页码：1563 / 1568

页数：6

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