Retinal ablation and altered lens differentiation induced by ocular overexpression of BMP7

被引：29

作者：

Hung, FC

Zhao, SL

Chen, Q

Overbeek, PA ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

VISION RESEARCH | 2002年 / 42卷 / 04期

关键词：

bone morphogenetic proteins; retinal apoptosis; lens; transgenic; mouse;

D O I：

10.1016/S0042-6989(01)00242-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The alphaA-crystallin promoter was used to target expression of bone morphogenetic protein 7 (BMP7) to lens fiber cells in transgenic mice. Surprisingly. lens-specific expression of BMP7 induced widespread apoptosis and rapid ablation or the neural retina in multiple families. Subsequent to retinal ablation, the lens bow region shifted posteriorly until lens epithelial cells completely enveloped the lens. Lens-specific expression of FGF3 was found to rescue the loss of fiber cell differentiation. Our results show that elevated BMP7 levels can induce rapid retinal degeneration accompanied by disruption of the endogenous ocular system for fiber cell induction. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：427 / 438

页数：12

相关论文

共 50 条

[41] Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism [J].

Tanaka, K ;

Pracyk, JB ;

Takeda, K ;

Yu, ZX ;

Ferrans, VJ ;

Deshpande, SS ;

Ozaki, M ;

Hwang, PM ;

Lowenstein, CJ ;

Irani, K ;

Finkel, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) :25922-25928

[42] Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells) [J].

Terkeltaub, RA ;

Johnson, K ;

Rohnow, D ;

Goomer, R ;

Burton, D ;

Deftos, LJ .

JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (06) :931-941

[43] Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT) [J].

Truett, GE ;

Heeger, P ;

Mynatt, RL ;

Truett, AA ;

Walker, JA ;

Warman, ML .

BIOTECHNIQUES, 2000, 29 (01) :52-+

[44] AGRIN IS A HEPARAN-SULFATE PROTEOGLYCAN [J].

TSEN, G ;

HALFTER, W ;

KROGER, S ;

COLE, GJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) :3392-3399

[45] BMP7 acts in murine lens placode development [J].

Wawersik, S ;

Purcell, P ;

Rauchman, M ;

Dudley, AT ;

Robertson, EJ ;

Maas, R .

DEVELOPMENTAL BIOLOGY, 1999, 207 (01) :176-188

[46] Cellular and molecular features of lens differentiation: A review of recent advances [J].

Wride, MA .

DIFFERENTIATION, 1996, 61 (02) :77-93

[47]

YAMAMOTO Y, 1976, DEV GROWTH DIFFER, V18, P273, DOI 10.1111/j.1440-169X.1976.00273.x

[48] BAD, A HETERODIMERIC PARTNER FOR BCL-X(L) AND BCL-2, DISPLACES BAX AND PROMOTES CELL-DEATH [J].

YANG, E ;

ZHA, JP ;

JOCKEL, J ;

BOISE, LH ;

THOMPSON, CB ;

KORSMEYER, SJ .

CELL, 1995, 80 (02) :285-291

[49] Cooperation between the Cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development [J].

Zhang, PM ;

Wong, C ;

DePinho, RA ;

Harper, JW ;

Elledge, SJ .

GENES & DEVELOPMENT, 1998, 12 (20) :3162-3167

[50] Requirement for BMP signaling in interdigital apoptosis and scale formation [J].

Zou, HY ;

Niswander, L .

SCIENCE, 1996, 272 (5262) :738-741

← 1 2 3 4 5 →