Limits to deficit accumulation in elderly peoplet

被引：172

作者：

Rockwood, K ^{[1
]}

Mitnitski, A ^{[1
]}

机构：

[1] Dalhousie Univ, Div Geriatr Med, Dept Med, Halifax, NS B3H 1C6, Canada

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2006年 / 127卷 / 05期

基金：

加拿大健康研究院;

关键词：

ageing; frailty (deficit accumulation) index; maximum; limits;

D O I：

10.1016/j.mad.2006.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We evaluated limits to the accumulation of deficits (symptoms, diseases, disabilities) for 33,069 people aged 65+ years. We combined deficits in a frailty index (theoretical range 0-1) and found that the 99% limit varied little between samples, representing a frailty index value of about 0.65 +/- 0.05. This near-maximum shows no relationship with age. It is the same in community and institutional samples, even though the mean value is much higher in the latter. The data suggest a level of frailty beyond which, even in developed countries, further deficit accumulation is not sustainable. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：494 / 496

页数：3

共 14 条

[1] Frailty index as a measure of biological age in a Chinese population [J].

Goggins, WB ;

Woo, J ;

Sham, A ;

Ho, SC .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2005, 60 (08) :1046-1051

[2] Standardization of the diagnosis of dementia in the Canadian Study of Health and Aging [J].

Graham, JE ;

Rockwood, K ;

Beattie, BL ;

McDowell, I ;

Eastwood, R ;

Gauthier, S .

NEUROEPIDEMIOLOGY, 1996, 15 (05) :246-256

[3] SELF-RATED HEALTH AND MORTALITY IN THE NHANES-I EPIDEMIOLOGIC FOLLOW-UP-STUDY [J].

IDLER, EL ;

ANGEL, RJ .

AMERICAN JOURNAL OF PUBLIC HEALTH, 1990, 80 (04) :446-452

[4] Do cognitive complaints either predict future cognitive decline or reflect past cognitive decline? A longitudinal study of an elderly community sample [J].

Jorm, AF ;

Christensen, H ;

Korten, AE ;

Henderson, AS ;

Jacomb, PA ;

Mackinnon, A .

PSYCHOLOGICAL MEDICINE, 1997, 27 (01) :91-98

[5]

MCDOWELL I, 1994, CAN MED ASSOC J, V150, P899

[6] Going from bad to worse: A stochastic model of transitions in deficit accumulation, in relation to mortality [J].

Mitnitski, A ;

Bao, L ;

Rockwood, K .

MECHANISMS OF AGEING AND DEVELOPMENT, 2006, 127 (05) :490-493

[7] Decrease in the relative heterogeneity of health with age: A cross-national comparison [J].

Mitnitski, A ;

Rockwood, K .

MECHANISMS OF AGEING AND DEVELOPMENT, 2006, 127 (01) :70-72

[8] Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality [J].

Mitnitski, A ;

Song, X ;

Skoog, I ;

Broe, GA ;

Cox, JL ;

Grunfeld, E ;

Rockwood, K .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2005, 53 (12) :2184-2189

[9]

Mitnitski A B, 2001, ScientificWorldJournal, V1, P323

[10] The estimation of relative fitness and frailty in community-dwelling older adults using self-report data [J].

Mitnitski, AB ;

Song, XW ;

Rockwood, K .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2004, 59 (06) :627-632

← 1 2 →