Double Couplings of Dibromothiophenes Using Boronic Acids and Boronates

被引：22

作者：

Varello, Samantha ^{[1
]}

Handy, Scott T. ^{[1
]}

机构：

[1] Middle Tennessee State Univ, Dept Chem, Murfreesboro, TN 37219 USA

来源：

SYNTHESIS-STUTTGART | 2009年 / 01期

关键词：

Suzuki couplings; regioselectivity; heteroaromatics; thiophenes; cross-coupling reactions; palladium catalysis; THIOPHENES;

D O I：

10.1055/s-0028-1083262

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot double couplings of dibromothiophenes have been investigated. Standard Suzuki couplings work well for 2,4-dibromothiophene, but are much more sensitive to steric effects in the case of 2,3-dibromothiophene. By using the recently reported potassium borates, though, good yields for both dibromothiophene isomers can be achieved.

引用

页码：138 / 142

页数：5

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