Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

被引：291

作者：

Faendrich, Marcus ^{[1
,2
]}

机构：

[1] Max Planck Res Unit Enzymol Prot Folding, D-01620 Halle, Saale, Germany

[2] Univ Halle Wittenberg, D-01620 Halle, Saale, Germany

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2012年 / 421卷 / 4-5期

关键词：

amyloid; protein folding disease; oligomer; intermediate; structure; A-BETA OLIGOMERS; MOLECULAR-DYNAMICS SIMULATIONS; ALZHEIMERS-DISEASE; FIBRIL FORMATION; IN-VITRO; PROTEIN OLIGOMERS; PRION PROTEIN; SYNAPTIC PLASTICITY; AGGREGATION KINETICS; MASS-SPECTROMETRY;

D O I：

10.1016/j.jmb.2012.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Focusing primarily on the oligomeric states formed from Alzheimer's disease beta-amyloid (A beta) peptide, this review will make references to other polypeptide systems, highlighting common principles or sequence-specific differences. The covered topics include the structural properties and polymorphism of oligomers, the biophysical mechanism of peptide self-assembly and its role for pathogenicity in amyloid disease. Oligomer-dependent toxicity mechanisms will be explained along with recently emerging possibilities of interference. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：427 / 440

页数：14

共 151 条

[1] Structural conversion of neurotoxic amyloid-β1-42 oligomers to fibrils [J].

Ahmed, Mahiuddin ;

Davis, Judianne ;

Aucoin, Darryl ;

Sato, Takeshi ;

Ahuja, Shivani ;

Aimoto, Saburo ;

Elliott, James I. ;

Van Nostrand, William E. ;

Smith, Steven O. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (05) :561-U56

[2] How is protein aggregation in amyloidogenic diseases modulated by biological membranes? [J].

Aisenbrey, Christopher ;

Borowik, Tomasz ;

Bystrom, Roberth ;

Bokvist, Marcus ;

Lindstrom, Fredrick ;

Misiak, Hanna ;

Sani, Marc-Antoine ;

Grobner, Gerhard .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2008, 37 (03) :247-255

[3] Amyloid fibril formation by Aβ16-22, a seven-residue fragment of the Alzheimer's β-amyloid peptide, and structural characterization by solid state NMR [J].

Balbach, JJ ;

Ishii, Y ;

Antzutkin, ON ;

Leapman, RD ;

Rizzo, NW ;

Dyda, F ;

Reed, J ;

Tycko, R .

BIOCHEMISTRY, 2000, 39 (45) :13748-13759

[4] Globular amyloid β-peptide1-42 oligomer -: a homogenous and stable neuropathological protein in Alzheimer's disease [J].

Barghorn, S ;

Nimmrich, V ;

Striebinger, A ;

Krantz, C ;

Keller, P ;

Janson, B ;

Bahr, M ;

Schmidt, M ;

Bitner, RS ;

Harlan, J ;

Barlow, E ;

Ebert, U ;

Hillen, H .

JOURNAL OF NEUROCHEMISTRY, 2005, 95 (03) :834-847

[5] Mitochondria take center stage in aging and neurodegeneration [J].

Beal, MF .

ANNALS OF NEUROLOGY, 2005, 58 (04) :495-505

[6]

Bernstein SL, 2009, NAT CHEM, V1, P326, DOI [10.1038/nchem.247, 10.1038/NCHEM.247]

[7] Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils [J].

Bieschke, Jan ;

Herbst, Martin ;

Wiglenda, Thomas ;

Friedrich, Ralf P. ;

Boeddrich, Annett ;

Schiele, Franziska ;

Kleckers, Daniela ;

del Amo, Juan Miguel Lopez ;

Gruening, Bjoern A. ;

Wang, Qinwen ;

Schmidt, Michael R. ;

Lurz, Rudi ;

Anwyl, Roger ;

Schnoegl, Sigrid ;

Faendrich, Marcus ;

Frank, Ronald F. ;

Reif, Bernd ;

Guenther, Stefan ;

Walsh, Dominic M. ;

Wanker, Erich E. .

NATURE CHEMICAL BIOLOGY, 2012, 8 (01) :93-101

[8] EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity [J].

Bieschke, Jan ;

Russ, Jenny ;

Friedrich, Ralf P. ;

Ehrnhoefer, Dagmar E. ;

Wobst, Heike ;

Neugebauer, Katja ;

Wanker, Erich E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (17) :7710-7715

[9] Amyloid β-protein (Aβ) assembly:: Aβ40 and Aβ42 oligomerize through distinct pathways [J].

Bitan, G ;

Kirkitadze, MD ;

Lomakin, A ;

Vollers, SS ;

Benedek, GB ;

Teplow, DB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :330-335

[10] Amyloid β-protein oligomerization -: Prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins [J].

Bitan, G ;

Lomakin, A ;

Teplow, DB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :35176-35184

← 1 2 3 4 5 6 7 8 9 10 →