Immunopotentiation of Caffeoyl Glycoside from Picrorhiza scrophulariiflora on activation and cytokines secretion of immunocyte in vitro

被引：20

作者：

Zeng, Sheng ^{[1
]}

Wang, Dacheng ^{[1
]}

Cao, Yongguo ^{[1
]}

An, Na ^{[1
]}

Zeng, Fanqin ^{[1
]}

Han, Chuntian ^{[1
]}

Song, Yu ^{[1
]}

Deng, Xuming ^{[1
]}

机构：

[1] Jilin Univ, Coll Anim Sci & Vet Med, Dept Vet Pharmacol, Changchun 130062, Jilin, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2008年 / 8卷 / 12期

关键词：

Picrorhiza Scrophulariiflora; Caffeoyl Glycoside; immuncrenhancement;

D O I：

10.1016/j.intimp.2008.07.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Many natural products have been used as immunomodulators either as immunosuppressants or immunostimulators. Recently, our lab has successfully isolated a 1,6-di-O-caffeoyl-beta-D-glucopyranoside, monomer named Caffeoyl Glycoside (CC) from the roots of Picrorhiza scrophulariiflora (Kutki). In the present study, we evaluated the effects of this compound on immunomodulation in vitro. Our results showed that CC Stimulated cell proliferation of splenocytes and peritoneal macrophages, and enhanced the cytotoxicity of natural killer (NK) cells significantly. CC also increased CD4 and CD8 cell populations. Moreover, we found that CC has immunomodulatory activity by regulating expression of Th1 and Th2 related cytokines. Taken together, these results indicated that CC might have potential effects in regulating the immune system, and this compound might be a useful immunotherapeutic agent in treating various immunity-related diseases. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：1707 / 1712

页数：6

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