Characterization of amphiphilic beta-cyclodextrin nanospheres

被引:33
作者
Skiba, M
Wouessidjewe, D
Puisieux, F
Duchene, D
Gulik, A
机构
[1] UNIV PARIS 11,CTR PHARMACEUT,URA CNRS 1218,LAB PHYSICOCHIM PHARMACOTECH & BIOPHARM,F-92290 CHATENAY MALABRY,FRANCE
[2] CTR GENET MOL,CNRS,F-91192 GIF SUR YVETTE,FRANCE
关键词
amphiphilic cyclodextrins; nanospheres; characterization;
D O I
10.1016/0378-5173(96)04653-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A new nanosphere carrier system was obtained from amphiphilic beta-cyclodextrins bearing fatty acids (with a chain length of either 6 or 12 or 14 carbon atoms) grafted at the O-2 and O-3 position of the beta-cyclodextrin molecule. Nanospheres, with a mean diameter of several hundred nm, were prepared by progressive dispersion. The nanospheres were characterized by their density, surface charge, size and morphology, using several techniques, namely centrifugation, zeta potential determination, quasi-elastic light scattering and freeze-fracture electron microscopy.
引用
收藏
页码:121 / 124
页数:4
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