Drug Resistance in Cancer: An Overview

被引：1815

作者：

Housman, Genevieve ^{[1
]}

Byler, Shannon ^{[2
]}

Heerboth, Sarah ^{[2
]}

Lapinska, Karolina ^{[2
]}

Longacre, Mckenna ^{[3
]}

Snyder, Nicole ^{[2
]}

Sarkar, Sibaji ^{[2
]}

机构：

[1] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA

[2] Boston Univ, Sch Med, Ctr Canc, Dept Med, Boston, MA 02118 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

来源：

CANCERS | 2014年 / 6卷 / 03期

关键词：

cancer; drug resistance; epigenetics; methylation; cancer progenitor cells; combination therapy; review; EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTIONAL DOWN-REGULATION; HISTONE DEACETYLASE INHIBITORS; DNA-REPAIR GENES; BREAST-CANCER; MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; COLORECTAL-CANCER; PROMOTER HYPERMETHYLATION; TAMOXIFEN RESISTANCE;

D O I：

10.3390/cancers6031769

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA damage repair, cell death inhibition, and the epithelial-mesenchymal transition, as well as how inherent tumor cell heterogeneity plays a role in drug resistance. It also describes the epigenetic modifications that can induce drug resistance and considers how such epigenetic factors may contribute to the development of cancer progenitor cells, which are not killed by conventional cancer therapies. Lastly, this review concludes with a discussion on the best treatment options for existing drug resistant cancers, ways to prevent the formation of drug resistant cancers and cancer progenitor cells, and future directions of study.

引用

页码：1769 / 1792

页数：24

共 113 条

[41] β3 Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells [J].

Galliher, Amy J. ;

Schiemann, William P. .

BREAST CANCER RESEARCH, 2006, 8 (04)

[42]

Goode EL, 2002, CANCER EPIDEM BIOMAR, V11, P1513

[43] Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification [J].

Gorre, ME ;

Mohammed, M ;

Ellwood, K ;

Hsu, N ;

Paquette, R ;

Rao, PN ;

Sawyers, CL .

SCIENCE, 2001, 293 (5531) :876-880

[44] Multidrug resistance in cancer: Role of ATP-dependent transporters [J].

Gottesman, MM ;

Fojo, T ;

Bates, SE .

NATURE REVIEWS CANCER, 2002, 2 (01) :48-58

[45] Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma [J].

Haber, M ;

Smith, J ;

Bordow, SB ;

Flemming, C ;

Cohn, SL ;

London, WB ;

Marshall, GM ;

Norris, MD .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (10) :1546-1553

[46] Use of Epigenetic Drugs in Disease: An Overview [J].

Heerboth, Sarah ;

Lapinska, Karolina ;

Snyder, Nicole ;

Leary, Meghan ;

Rollinson, Sarah ;

Sarkar, Sibaji .

GENETICS & EPIGENETICS, 2014, 6 :9-19

[47] MGMT gene silencing and benefit from temozolomide in glioblastoma [J].

Hegi, ME ;

Diserens, A ;

Gorlia, T ;

Hamou, M ;

de Tribolet, N ;

Weller, M ;

Kros, JM ;

Hainfellner, JA ;

Mason, W ;

Mariani, L ;

Bromberg, JEC ;

Hau, P ;

Mirimanoff, RO ;

Cairncross, JG ;

Janzer, RC ;

Stupp, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (10) :997-1003

[48] Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines [J].

Hilgendorf, Constanze ;

Ahlin, Gustav ;

Seithel, Annick ;

Artursson, Per ;

Ungell, Anna-Lena ;

Karlsson, Johan .

DRUG METABOLISM AND DISPOSITION, 2007, 35 (08) :1333-1340

[49]

HINDS M, 1991, CANCER RES, V51, P4729

[50] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in k562 cells [J].

Hirayama, Chie ;

Watanabe, Hiroshi ;

Nakashima, Reiko ;

Nanbu, Takeru ;

Hamada, Akinobu ;

Kuniyasu, Akihiko ;

Nakayama, Hitoshi ;

Kawaguchi, Tatsuya ;

Saito, Hideyuki .

PHARMACEUTICAL RESEARCH, 2008, 25 (04) :827-835

← 1 2 3 4 5 6 7 8 9 10 →