Metabolic maps and functions of the Plasmodium falciparum apicoplast

被引：486

作者：

Ralph, SA

van Dooren, GG

Waller, RF

Crawford, MJ

Fraunholz, MJ

Foth, BJ

Tonkin, CJ

Roos, DS

McFadden, GI ^{[1
]}

机构：

[1] Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Melbourne, Vic 3010, Australia

[2] Inst Pasteur, F-75724 Paris, France

[3] Univ British Columbia, Dept Bot, Canadian Inst Adv Res, Program Evolutionary Biol, Vancouver, BC V6T 1Z4, Canada

[4] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[5] Univ Penn, Genom Inst, Philadelphia, PA 19104 USA

[6] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrmicro843

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new opportunities for drug development. The apicoplast - although no longer photosynthetic - is essential to parasites. Combining bioinformatics approaches with experimental validation in the laborator we have identified more than 500 proteins predicted to function in the apicoplast, By comparison with plant chloroplasts, we have reconstructed several anabolic pathways for the parasite plastid that are fundamentally different to the analogous pathways in the human host and are potentially good targets for drug development. Products of these pathways seem to be exported from the apicoplast and might be involved in host-cell invasion.

引用

页码：203 / 216

页数：14

共 184 条

[31] The N′-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes [J].