Is T-cell priming required for initiation of pathology in malaria infections?

被引：68

作者：

Riley, EM ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-5699(99)01456-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathology of malaria infection is mediated in part by components of the innate immune system, particularly tumour necrosis factor alpha, but the relationship between malaria infection and disease is not straightforward. Here, Eleanor Riley proposes that T-cell priming is required for amplification of the inflammatory response to malaria and that this explains patterns of clinical malaria in both endemic and non-endemic populations.

引用

页码：228 / 233

页数：6

共 53 条

[1] Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production nitric oxide synthase type 2 expression [J].

Anstey, NM ;

Weinberg, JB ;

Hassanali, M ;

Mwaikambo, ED ;

Manyenga, D ;

Misukonis, MA ;

Arnelle, DR ;

Hollis, D ;

McDonald, MI ;

Granger, DL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :557-567

[2] Age-dependent susceptibility to severe disease with primary exposure to Plasmodium falciparum [J].

Baird, JK ;

Masbar, S ;

Basri, H ;

Tirtokusumo, S ;

Subianto, B ;

Hoffman, SL .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (02) :592-595

[3] HOST AGE AS A DETERMINANT OF NATURALLY ACQUIRED-IMMUNITY TO PLASMODIUM-FALCIPARUM [J].

BAIRD, JK .

PARASITOLOGY TODAY, 1995, 11 (03) :105-111

[4]

Bastien P, 1987, Med Trop (Mars), V47, P125

[5] PREFERENTIAL EXPANSION OF V-GAMMA-9 V-DELTA-2 T-CELLS FOLLOWING STIMULATION OF PERIPHERAL-BLOOD LYMPHOCYTES WITH EXTRACTS OF PLASMODIUM-FALCIPARUM [J].

BEHR, C ;

DUBOIS, P .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (03) :361-366

[6] Plasmodium falciparum stimuli for human gamma delta T cells are related to phosphorylated antigens of mycobacteria [J].

Behr, C ;

Poupot, R ;

Peyrat, MA ;

Poquet, Y ;

Constant, P ;

Dubois, P ;

Bonneville, M ;

Fournie, JJ .

INFECTION AND IMMUNITY, 1996, 64 (08) :2892-2896

[7]

Brabin B., 1990, TROP DIS B, V87, P1

[8]

CHIZZOLINI C, 1990, CLIN EXP IMMUNOL, V79, P95, DOI 10.1111/j.1365-2249.1990.tb05133.x

[9] ANTIGENS RELEASED AT SCHIZONT BURST STIMULATE PLASMODIUM FALCIPARUM-SPECIFIC CD4(+) T-CELLS FROM NON-EXPOSED DONORS - POTENTIAL FOR CROSS-REACTIVE MEMORY T-CELLS TO CAUSE DISEASE [J].

CURRIER, J ;

BECK, HP ;

CURRIE, B ;

GOOD, MF .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (05) :821-833

[10] NATURAL T-CELLS RESPONSIVE TO MALARIA - EVIDENCE IMPLICATING IMMUNOLOGICAL CROSS-REACTIVITY IN THE MAINTENANCE OF TCR-ALPHA-BETA+ MALARIA-SPECIFIC RESPONSES FROM NONEXPOSED DONORS [J].

CURRIER, J ;

SATTABONGKOT, J ;

GOOD, MF .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (09) :985-994

← 1 2 3 4 5 6 →