Anti-inflammatory substances a new therapeutic option in Alzheimer's disease

被引：24

作者：

Hüll, M ^{[1
]}

Fiebich, BL ^{[1
]}

Schumann, G ^{[1
]}

Lieb, K ^{[1
]}

Bauer, J ^{[1
]}

机构：

[1] Univ Freiburg, Sch Med, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany

来源：

DRUG DISCOVERY TODAY | 1999年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1359-6446(99)01339-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Among several pathogenetic elements underlying Alzheimer's disease (AD), a brain-specific in flammatory response has recently attracted attention as a cause of neurodegeneration and progressive cognitive decline. Markers of inflammation in AD are activated microglial cells, synthesis of cytokines, acute-phase proteins and complement proteins in areas of brain destruction. Epidemiological studies point to a reduced risk of AD among users of anti-inflammatory drugs. Influencing inflammatory parameters has become the focus of several new treatment strategies and a clinical trial with indomethacin shows promising results. The results from current clinical trials with steroidal and non-steroidal anti-inflammatory drugs will be available in the near future.

引用

页码：275 / 282

页数：8

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