Sulfated zirconia, a mild alternative to mineral acids in the synthesis of hydroxycoumarins

被引:43
作者
Rodríguez-Domínguez, JC
Kirsch, G
机构
[1] Univ Metz, Lab Ingn Mol & Biochem Pharmacol, F-57078 Metz, France
[2] Ctr Quim Farmaceut, Dept Quim, Havana 11600, Cuba
关键词
coumarins; Pechmann's reaction;
D O I
10.1016/j.tetlet.2006.03.030
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Sulfated zirconia (1%) was employed as Pechmann's catalyst without solvent or in some cases using a small amount of ethanol to obtain coumarins in moderate to good yields. With this procedure, no significant acidic waste was obtained and an environmental friendly alternative to obtain coumarins is provided. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码:3279 / 3281
页数:3
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