Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24

被引：29

作者：

Boomsma, DI

Cacioppo, JT

Slagboom, PE

Posthuma, D

机构：

[1] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

[2] Univ Chicago, Chicago, IL 60637 USA

[3] Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands

来源：

BEHAVIOR GENETICS | 2006年 / 36卷 / 01期

关键词：

association; heritability; linkage; loneliness; ordinal data; QTL; sib-pair;

D O I：

10.1007/s10519-005-9005-z

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We obtained evidence from a large study in Dutch twins (N=8387) and siblings (N=2295) that variation in loneliness has a genetic component. The heritability estimate for loneliness, which was assessed as an ordinal trait, was 40% and did not differ between males and females. There were 682 sibling pairs with genotypic (around 400 microsatellite markers) data. We combined phenotypic and genotypic data to carry out a genome scan to localize QTLs for loneliness. One region on chromosome 12q23.3-24.3, showed near suggestive linkage. Genetic association tests within this region revealed significant association (p-value 0.009) with one of the alleles of marker D12S79 and with one of the alleles of neighbouring marker D12S395 (p-value 0.043). We review evidence for linkage in this region for psychiatric disorders and discuss our findings within this context.

引用

页码：137 / 146

页数：10

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