Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

被引：158

作者：

Prescott, JH ^{[1
]}

Lipka, S ^{[1
]}

Baldwin, S ^{[1
]}

Sheppard, NF ^{[1
]}

Maloney, JM ^{[1
]}

Coppeta, J ^{[1
]}

Yomtov, B ^{[1
]}

Staples, MA ^{[1
]}

Santini, JT ^{[1
]}

机构：

[1] MicroCHIPS Inc, Bedford, MA 01730 USA

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 04期

关键词：

D O I：

10.1038/nbt1199

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

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页码：437 / 438

页数：2

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