A controlled-release microchip

被引:687
作者
Santini, JT
Cima, MJ
Langer, R
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
关键词
D O I
10.1038/16898
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Much previous work in methods of achieving complex drug-release patterns has focused on pulsatile release from polymeric materials in response to specific stimuli(1), such as electric(2-5) or magnetic(6,7) fields, exposure to ultrasound(7,8), light(9) or enzymes(10), and changes in pH(11) or temperature(12-14), An alternative method for achieving pulsatile release involves using microfabrication technology to develop active devices that incorporate micrometre-scale pumps, valves and flow channels to deliver liquid solutions(15,16). Here we report a solid-state silicon microchip that can provide controlled release of single or multiple chemical substances on demand. The release mechanism is based on the electrochemical dissolution of thin anode membranes covering microreservoirs filled with chemicals in solid, liquid or gel form. We have conducted proof-of-principle release studies with a prototype microchip using gold and saline solution as a model electrode material and release medium, and we have demonstrated controlled, pulsatile release of chemical substances with this device.
引用
收藏
页码:335 / 338
页数:4
相关论文
共 22 条
[1]  
BAE YH, 1987, MAKROMOL CHEM-RAPID, V8, P481
[2]  
BAE YH, 1994, POLYM DRUGS DRUG ADM, P98
[3]   REGULATION OF DRUG RELEASE FROM POLYMER MATRICES BY OSCILLATING MAGNETIC-FIELDS [J].
EDELMAN, ER ;
KOST, J ;
BOBECK, H ;
LANGER, R .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1985, 19 (01) :67-83
[4]   ENZYMATICALLY CONTROLLED DRUG DELIVERY [J].
FISCHELGHODSIAN, F ;
BROWN, L ;
MATHIOWITZ, E ;
BRANDENBURG, D ;
LANGER, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2403-2406
[5]   THE ANODIC CORROSION OF GOLD IN CONCENTRATED CHLORIDE SOLUTIONS [J].
FRANKENTHAL, RP ;
SICONOLFI, DJ .
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 1982, 129 (06) :1192-1196
[6]   Microfluidics - a review [J].
Gravesen, Peter ;
Branebjerg, Jens ;
Jensen, Ole Sondergard .
Journal of Micromechanics and Microengineering, 1993, 3 (04) :168-182
[7]  
HEPEL M, 1994, POLYM DRUGS DRUG ADM, P79
[8]  
HOFFMAN A S, 1986, Journal of Controlled Release, V4, P213
[9]  
Jaeger R., 1988, INTRO MICROELECTRONI
[10]   CAPILLARY INSTABILITIES IN THIN, CONTINUOUS FILMS [J].
JIRAN, E ;
THOMPSON, CV .
THIN SOLID FILMS, 1992, 208 (01) :23-28