Nanoscale theranostics for physical stimulus-responsive cancer therapies

被引：183

作者：

Chen, Qian ^{[1
]}

Ke, Hengte ^{[2
]}

Dai, Zhifei ^{[3
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China

[3] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China

来源：

BIOMATERIALS | 2015年 / 73卷

基金：

中国国家自然科学基金;

关键词：

Physical stimulus; Theranostics; Cancer therapies; SUPERPARAMAGNETIC IRON-OXIDE; INTENSITY FOCUSED ULTRASOUND; UP-CONVERSION NANOPARTICLES; GUIDED PHOTOTHERMAL THERAPY; VIVO PHOTODYNAMIC THERAPY; LOCALIZED PROSTATE-CANCER; TRIGGERED DRUG-DELIVERY; GOLD NANOPARTICLES; MAGNETIC NANOPARTICLES; CARBON NANOTUBES;

D O I：

10.1016/j.biomaterials.2015.09.018

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Physical stimulus-responsive therapies often employing multifunctional theranostic agents responsive to external physical stimuli such as light, magnetic field, ultra-sound, radiofrequency, X-ray, etc., have been widely explored as novel cancer therapy strategies, showing encouraging results in many pre-clinical animal experiments. Unlike conventional cancer chemotherapy which often accompanies with severe toxic side effects, physical stimulus-responsive agents usually are non-toxic by themselves and would destruct cancer cells only under specific external stimuli, and thus could offer greatly reduced toxicity and enhanced treatment specificity. In addition, physical stimulus-responsive therapies can also be combined with other traditional therapeutics to achieve synergistic anti-tumor effects via a variety of mechanisms. In this review, we will summarize the latest progress in the development of physical stimulus-responsive therapies, and discuss the important roles of nanoscale theranostic agents involved in those non-conventional therapeutic strategies. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：214 / 230

页数：17

共 230 条

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