Current status of chemokine receptor inhibitors in development

被引：52

作者：

Allegretti, Marcello ^{[1
]}

Cesta, Maria Candida ^{[1
]}

Garin, Alexandre ^{[2
]}

Proudfoot, Amanda E. I. ^{[2
]}

机构：

[1] Dompe Spa, I-67100 Laquila, Italy

[2] Merck Serono SA, CH-1202 Geneva, Switzerland

来源：

IMMUNOLOGY LETTERS | 2012年 / 145卷 / 1-2期

关键词：

Chemokine; CXC; CC receptor antagonists; Allosteric inhibitors; HIV; Inflammatory diseases; MOLECULAR-WEIGHT ANTAGONIST; INDUCED AIRWAY INFLAMMATION; COLLAGEN-INDUCED ARTHRITIS; DIFFERENTIAL EXPRESSION; MULTIPLE-SCLEROSIS; CXC CHEMOKINES; CCR5; DELTA-32; HIV-1; ENTRY; PHARMACOLOGICAL CHARACTERIZATION; CHEMOTACTIC RESPONSIVENESS;

D O I：

10.1016/j.imlet.2012.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The chemokine network plays pivotal role in a large number of inflammatory, allergic and autoimmune diseases, as well as in the promotion of tumor growth and metastasis. Considerable effort has been put in the pharmaceutical industry to identify therapeutic agents that specifically target chemokine receptors. Despite the fact that several promising programs have proven unsuccessful in Phase II trials the research activity both in academia and industry is still highly intense, whereas for some of the chemokine receptors the progress is still at the preclinical stage. In this review the authors discuss possible reasons beyond successes and failures of early clinical development programs and discuss the most relevant and recent pharmacological approaches with the aim to point out new theories, open issues and expectations in this research field. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：68 / 78

页数：11

共 141 条

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