Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings

被引：63

作者：

Ceriello, Antonio ^{[1
]}

机构：

[1] Univ Hosp, Clin Sci Res Inst, Warwick Med Sch, Coventry CV2 2DX, W Midlands, England

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2008年 / 5卷 / 04期

关键词：

endothelial dysfunction; oxidative stress; postprandial hyperglycaemia;

D O I：

10.3132/dvdr.2008.038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.

引用

页码：260 / 268

页数：9

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