Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B

被引：51

作者：

Holschneider, DP

Chen, K

Seif, I

Shih, JC

机构：

[1] Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90089 USA

[2] Univ So Calif, Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90033 USA

[3] Univ So Calif, Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

[4] Greater Los Angeles VA Healthcare Syst, Los Angeles, CA USA

[5] Inst Curie, CNRS, Unite Mixte Rech 146, F-91405 Orsay, France

[6] Univ So Calif, Sch Med, Dept Cell & Neurobiol, Los Angeles, CA USA

来源：

BRAIN RESEARCH BULLETIN | 2001年 / 56卷 / 05期

关键词：

monoamine oxidase; serotonin; norepinephrine; phenylethylamine; dopamine;

D O I：

10.1016/S0361-9230(01)00613-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine. This paper summarizes some of the current known phenotypic findings in MAO A knock-out mice and contrast these with those of MAO B knock-out mice. Differences are discussed in relation to the biochemical, behavioral, and physiologic changes investigated to date, as well as the role played by redundancy mechanisms, adaptational responses, and alterations in neurodevelopment. (C) 2001 Elsevier Science Inc.

引用

页码：453 / 462

页数：10

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