Diastereoselective nucleophilic additions to vinyl phosphine oxides

被引：25

作者：

Bartels, B ^{[1
]}

Clayden, J ^{[1
]}

Martín, CG ^{[1
]}

Nelson, A ^{[1
]}

Russell, MG ^{[1
]}

Warren, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 13期

关键词：

D O I：

10.1039/a902414j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some hydrogen, carbon, silicon, sulfur, nitrogen and oxygen nucleophiles react diastereoselectively with gamma-oxygenated chiral vinyl phosphine oxides to give beta-substituted phosphine oxides. Lithium N-benzyl-alpha-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, beta-amino phosphine oxides as single diastereoisomers.

引用

页码：1807 / 1822

页数：16

共 51 条

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