Asymmetric addition of Davies's chiral lithium amide to prochiral vinyl phosphine oxides

被引：14

作者：

Bartels, B ^{[1
]}

Martín, CG ^{[1
]}

Nelson, A ^{[1
]}

Russell, MG ^{[1
]}

Warren, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)10860-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithium N-benzyl-alpha-methylbenzylamide adds to prochiral vinyl phosphine oxides in the presence of trimethylsilyl chloride to provide, after protodesilylation, beta-amino phosphine oxides as single diastereoisomers. A mechanism which explains the role of trimethylsilyl chloride is proposed. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1637 / 1640

页数：4

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