Antiperoxidative components in Thymus vulgaris

被引：65

作者：

Haraguchi, H ^{[1
]}

Saito, T ^{[1
]}

Ishikawa, H ^{[1
]}

Date, H ^{[1
]}

Kataoka, S ^{[1
]}

Tamura, Y ^{[1
]}

Mizutani, K ^{[1
]}

机构：

[1] MARUZEN PHARMACEUT CO LTD, BIOL & CHEM LAB, FUKUYAMA, HIROSHIMA 72901, JAPAN

来源：

PLANTA MEDICA | 1996年 / 62卷 / 03期

关键词：

Thymus vulgaris L; Labiatae; 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl; eriodicytol; lipid peroxidation; superoxide anion;

D O I：

10.1055/s-2006-957863

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A biphenyl compound, 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1), and a flavonoid, eriodicytol (2), were isolated as antioxidative components from the leaves of Thymus vulgaris by bioassay-directed fractionation. These compounds inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited by these compounds. Compound 1 is an extremely potent antioxidant; complete inhibition was observed at 1 mu M against both microsomal and mitochondrial peroxidation. Furthermore, compound 1 protected red cells against oxidative hemolysis. These phenolic compounds were shown to be effective to protect biological systems against various oxidative stresses.

引用

页码：217 / 221

页数：5

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