The ESCRT machinery: new functions in viral and cellular biology

被引：59

作者：

Carlton, Jeremy G. ^{[1
]}

Martin-Serrano, Juan ^{[1
]}

机构：

[1] Guys Hosp, Univ London Kings Coll, Sch Med, Dept Infect Dis, London SE1 9RT, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

基金：

英国医学研究理事会;

关键词：

endosomal sorting complex required for transport (ESCRT); multivesicular body (MVB); retrovirus; tumour susceptibility gene 101 (Tsg101); vacuolar protein sorting 4 (Vps4); virus; IMMUNODEFICIENCY-VIRUS TYPE-1; PROTEIN-SORTING PATHWAY; LATE-BUDDING DOMAINS; ROUS-SARCOMA-VIRUS; YPXL LATE DOMAINS; PARTICLE RELEASE; STRUCTURAL BASIS; HIV-1; P6; UBIQUITIN; CYTOKINESIS;

D O I：

10.1042/BST0370195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESCRT (endosomal sorting complex required for transport) machinery consists of a number of cytosolic proteins that make up three functional subcomplexes: ESCRT-I, ESCRT-II and ESCRT-III. These proteins function in multivesicular body formation and cell division and are co-opted by enveloped retroviruses to facilitate viral egress. Analysis of these functions may help illuminate conserved mechanisms of ESCRT function.

引用

页码：195 / 199

页数：5

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