Regulation of dynorphin gene expression by κ-opioid agonist treatment

被引：10

作者：

Collins, S

D'Addario, C

Romualdi, P

Candeletti, S

Izenwasser, S

机构：

[1] Univ Miami, Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

[2] Univ Bologna, Dept Pharmacol, I-40126 Bologna, Italy

来源：

NEUROREPORT | 2002年 / 13卷 / 01期

关键词：

cocaine; dynorphin; kappa-opioid receptor; U-69593;

D O I：

10.1097/00001756-200201210-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of kappa-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective kappa-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that kappa-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression. NeuroReport 13:107-109 (C) 2002 Lippincott Williams Wilkins.

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收藏

页码：107 / 109

页数：3

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