THE KAPPA-OPIOID RECEPTOR AGONIST U-69593 ATTENUATES COCAINE-INDUCED BEHAVIORAL SENSITIZATION IN THE RAT

被引：123

作者：

HEIDBREDER, CA ^{[1
]}

GOLDBERG, SR ^{[1
]}

SHIPPENBERG, TS ^{[1
]}

机构：

[1] NIDA, BEHAV PHARMACOL & GENET SECT, PRECLIN PHARMACOL LAB, POB 5180, BALTIMORE, MD 21224 USA

来源：

BRAIN RESEARCH | 1993年 / 616卷 / 1-2期

关键词：

COCAINE; U-69593; KAPPA-OPIOID; LOCOMOTOR ACTIVITY; STEREOTYPY;

D O I：

10.1016/0006-8993(93)90228-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of treatment with the selective kappa-opioid receptor agonist U-69593 upon cocaine-induced changes in locomotor activity and stereotypy were examined in rats. U-69593 (0.16 mg/kg s1.c.) administered either acutely or chronically attenuated both the motor stimulant effect and stereotypy produced by an acute injection of cocaine (20 mg/kg i.p.). Daily cocaine treatment resulted in sensitization to both effects of cocaine. In contrast, no such sensitized responses were seen in animals which had received U-69593 either prior to or in conjunction with daily cocaine treatment. These data demonstrate that activation of kappa-opioid receptors attenuates the acute and chronic effects of cocaine on locomotor activity and stereotypy. Given the inhibitory effects ascribed to both exogenous and endogenous kappa-opioid agonists upon dopamine release in the mesolimbic dopaminergic system, it is suggested that this action may underlie the observed effects of U-69593 on cocaine-induced changes in locomotor activity and stereotypy.

引用

页码：335 / 338

页数：4

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