THE KAPPA-OPIOID RECEPTOR AGONIST U-69593 ATTENUATES COCAINE-INDUCED BEHAVIORAL SENSITIZATION IN THE RAT

被引：123

作者：

HEIDBREDER, CA ^{[1
]}

GOLDBERG, SR ^{[1
]}

SHIPPENBERG, TS ^{[1
]}

机构：

[1] NIDA, BEHAV PHARMACOL & GENET SECT, PRECLIN PHARMACOL LAB, POB 5180, BALTIMORE, MD 21224 USA

来源：

BRAIN RESEARCH | 1993年 / 616卷 / 1-2期

关键词：

COCAINE; U-69593; KAPPA-OPIOID; LOCOMOTOR ACTIVITY; STEREOTYPY;

D O I：

10.1016/0006-8993(93)90228-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of treatment with the selective kappa-opioid receptor agonist U-69593 upon cocaine-induced changes in locomotor activity and stereotypy were examined in rats. U-69593 (0.16 mg/kg s1.c.) administered either acutely or chronically attenuated both the motor stimulant effect and stereotypy produced by an acute injection of cocaine (20 mg/kg i.p.). Daily cocaine treatment resulted in sensitization to both effects of cocaine. In contrast, no such sensitized responses were seen in animals which had received U-69593 either prior to or in conjunction with daily cocaine treatment. These data demonstrate that activation of kappa-opioid receptors attenuates the acute and chronic effects of cocaine on locomotor activity and stereotypy. Given the inhibitory effects ascribed to both exogenous and endogenous kappa-opioid agonists upon dopamine release in the mesolimbic dopaminergic system, it is suggested that this action may underlie the observed effects of U-69593 on cocaine-induced changes in locomotor activity and stereotypy.

引用

页码：335 / 338

页数：4

共 30 条

[11] [H-3]U-69593 A HIGHLY SELECTIVE LIGAND FOR THE OPIOID K-RECEPTOR [J].

LAHTI, RA ;

MICKELSON, MM ;

MCCALL, JM ;

VONVOIGTLANDER, PF .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 109 (02) :281-284

[12] ANATOMY OF CNS OPIOID RECEPTORS [J].

MANSOUR, A ;

KHACHATURIAN, H ;

LEWIS, ME ;

AKIL, H ;

WATSON, SJ .

TRENDS IN NEUROSCIENCES, 1988, 11 (07) :308-314

[13]

MANZANARES J, 1991, J PHARMACOL EXP THER, V256, P500

[14] MOTIVATIONAL PROPERTIES OF KAPPA AND MU OPIOID RECEPTOR AGONISTS STUDIED WITH PLACE AND TASTE PREFERENCE CONDITIONING [J].

MUCHA, RF ;

HERZ, A .

PSYCHOPHARMACOLOGY, 1985, 86 (03) :274-280

[15] AUTORADIOGRAPHY OF [H-3] U-69593 BINDING-SITES IN RAT-BRAIN - EVIDENCE FOR KAPPA-OPIOID RECEPTOR SUBTYPES [J].

NOCK, B ;

RAJPARA, A ;

OCONNOR, LH ;

CICERO, TJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 154 (01) :27-34

[16] PSYCHOTOMIMESIS MEDIATED BY KAPPA-OPIATE RECEPTORS [J].

PFEIFFER, A ;

BRANTL, V ;

HERZ, A ;

EMRICH, HM .

SCIENCE, 1986, 233 (4765) :774-776

[17]

Post R. M., 1983, STIMULANTS NEUROCHEM, P169

[18] STRUCTURAL REQUIREMENTS FOR COCAINE CONGENERS TO INTERACT WITH DOPAMINE AND SEROTONIN UPTAKE SITES IN MOUSE-BRAIN AND TO INDUCE STEREOTYPED BEHAVIOR [J].

REITH, MEA ;

MEISLER, BE ;

SERSHEN, H ;

LAJTHA, A .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (07) :1123-1129

[19] COCAINE RECEPTORS ON DOPAMINE TRANSPORTERS ARE RELATED TO SELF-ADMINISTRATION OF COCAINE [J].

RITZ, MC ;

LAMB, RJ ;

GOLDBERG, SR ;

KUHAR, MJ .

SCIENCE, 1987, 237 (4819) :1219-1223

[20] PLACE PREFERENCE CONDITIONING REVEALS THE INVOLVEMENT OF D1-DOPAMINE RECEPTORS IN THE MOTIVATIONAL PROPERTIES OF MU-OPIOID AND KAPPA-OPIOID AGONISTS [J].

SHIPPENBERG, TS ;

HERZ, A .

BRAIN RESEARCH, 1987, 436 (01) :169-172

← 1 2 3 →