Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

被引：88

作者：

Anisimov, V. N. ^{[2
]}

Bakeeva, L. E. ^{[1
]}

Egormin, P. A. ^{[2
]}

Filenko, O. F. ^{[3
]}

Isakova, E. F. ^{[3
]}

Manskikh, V. N. ^{[4
]}

Mikhelson, V. M. ^{[5
]}

Panteleeva, A. A. ^{[1
]}

Pasyukova, E. G. ^{[6
]}

Pilipenko, D. I. ^{[1
]}

Piskunova, T. S. ^{[2
]}

Popovich, I. G. ^{[2
]}

Roshchina, N. V. ^{[6
]}

Rybina, O. Yu. ^{[6
]}

Saprunova, V. B. ^{[1
]}

Samoylova, T. A. ^{[3
]}

Semenchenko, A. V. ^{[2
]}

Skulachev, M. V. ^{[4
]}

Spivak, I. M. ^{[5
]}

Tsybul'ko, E. A. ^{[6
]}

Tyndyk, M. L. ^{[2
]}

Vyssokikh, M. Yu. ^{[1
]}

Yurova, M. N. ^{[2
]}

Zabezhinsky, M. A. ^{[2
]}

Skulachev, V. P. ^{[1
,4
,7
]}

机构：

[1] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[2] Petrov Inst Oncol, St Petersburg 197758, Russia

[3] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119991, Russia

[4] Moscow MV Lomonosov State Univ, Mitoengn Ctr, Moscow 119991, Russia

[5] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia

[6] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

[7] Moscow MV Lomonosov State Univ, Fac Bioengn & Bioinformat, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 12期

关键词：

SkQ1; antioxidants; mitochondria; aging; senescence; therapy;

D O I：

10.1134/S0006297908120055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.

引用

页码：1329 / 1342

页数：14

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