Hemisynthesis of rhazinilam analogues: Structure-activity relationships on tubulin-microtubule system

被引:53
作者
David, B
Sevenet, T
Thoison, O
Awang, K
Pais, M
Wright, M
Guenard, D
机构
[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
[2] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,TOULOUSE,FRANCE
关键词
D O I
10.1016/S0960-894X(97)00391-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:2155 / 2158
页数:4
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