Hemisynthesis of rhazinilam analogues: Structure-activity relationships on tubulin-microtubule system

被引：53

作者：

David, B

Sevenet, T

Thoison, O

Awang, K

Pais, M

Wright, M

Guenard, D

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,TOULOUSE,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00391-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed. (C) 1997 Elsevier Science Ltd.

引用

页码：2155 / 2158

页数：4