Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene

被引:367
作者
Prud'homme, B
Gompel, N
Rokas, A
Kassner, VA
Williams, TM
Yeh, SD
True, JR
Carroll, SB
机构
[1] Univ Wisconsin, Madison, WI 53706 USA
[2] Howard Hughes Med Inst, Bock Labs, Madison, WI 53706 USA
[3] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
[4] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA
关键词
D O I
10.1038/nature04597
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The independent evolution of morphological similarities is widespread(1,2). For simple traits, such as overall body colour, repeated transitions by means of mutations in the same gene may be common(3-5). However, for more complex traits, the possible genetic paths may be more numerous; the molecular mechanisms underlying their independent origins and the extent to which they are constrained to follow certain genetic paths are largely unknown. Here we show that a male wing pigmentation pattern involved in courtship display has been gained and lost multiple times in a Drosophila clade. Each of the cases we have analysed (two gains and two losses) involved regulatory changes at the pleiotropic pigmentation gene yellow. Losses involved the parallel inactivation of the same cis-regulatory element (CRE), with changes at a few nucleotides sufficient to account for the functional divergence of one element between two sibling species. Surprisingly, two independent gains of wing spots resulted from the co-option of distinct ancestral CREs. These results demonstrate how the functional diversification of the modular CREs of pleiotropic genes contributes to evolutionary novelty and the independent evolution of morphological similarities.
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页码:1050 / 1053
页数:4
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