Iridoid glycosides from Callicarpa nudiflora Hook

被引：42

作者：

Feng, Shi-Xiu ^{[1
,2
]}

Yi, Bo ^{[3
]}

Zhang, Min ^{[1
,2
]}

Xu, Jing ^{[1
,2
]}

Lin, Hai ^{[3
]}

Xu, Wen-Tong ^{[3
]}

机构：

[1] Fairy Lake Bot Garden, Key Lab South Subtrop Plant Divers, Shenzhen, Peoples R China

[2] Chinese Acad Sci, Shenzhen, Peoples R China

[3] Peoples Liberat Army, Hosp 187, Pharm Dept, Haikou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Callicarpa nudiflora; iridoid glycosides; cytotoxic activity;

D O I：

10.1080/14786419.2016.1224872

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Four new iridoid glycoside derivatives (1-4), along with ten known iridoid glycosides (5-14), were isolated from Callicarpa nudiflora Hook et Arn. The structure of the new iridoid glycosides was elucidated as 5 ''-methoxy-ampicoside (1), 6 ''-O-trans-caffeoylcatalpol (2), 6 ''-Otrans-feruloylcatalpol (3) and 3 ''-methoxy-agnucastoside C (4) on the basis of spectroscopic analysis. Compounds 1-11 were reported from this plant for the first time. The cytotoxic activity of the isolated compounds against human cervical carcinoma Hela cells and ovarian carcinoma HeyA8 cells was evaluated using the microculture tetrazolium assay. Compounds 4, 5, 8, 12 and 13 showed cytotoxic activity against the Hela cell line with IC50 values of 25.3, 48.1, 17.3, 38.3 and 28.2 mu M, respectively. While only compound 8 showed cytotoxicity against the HeyA8 cell line, with an IC50 of 35.5 mu M [GRAPHICS] .

引用

页码：181 / 189

页数：9

共 14 条

[1]

Akdemir ZS, 2004, TURK J CHEM, V28, P227

[2]

Iridoids and secoiridoids from Gentiana linearis [J].